Anti-Human CD275/ICOSLG Recombinant Antibody (SAA0089), APC (HF564137)

Name: Anti-Human CD275/ICOSLG Recombinant Antibody (SAA0089), APC
Brand: abinScience
SKU: HF564137
Price: 290 USD
Availability: InStock

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개요
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개요

카탈로그 번호	HF564137
종 반응성	Human
응용 분야	FCM
숙주 종	Human
클론성	Monoclonal
이소타입	IgG2, kappa
클론 ID	SAA0089
접합	APC
타겟	B7RP1, B7-related protein 1, CD275, ICOSL, ICOSLG, KIAA0653, B7 homolog 2, ICOS ligand, B7RP-1, B7H2, B7-H2, B7-like protein Gl50
내독소 수준	Please contact with the lab for this information.
관련 제품	Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10), APC
등록번호	O75144
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Store at 4°C for 12 months. Protect from light. Do not freeze.
배경	ICOS ligand (CD275/ICOSLG) is a ~33 kDa protein. Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion. Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP). 1. Yoshinaga, SK. et al. (2000) International immunology 12, 1439-47. PMID: 11007762 2. Wang, S. et al. (2000) Blood 96, 2808-13. PMID: 11023515 3. Roussel, L. et al. (2018) The Journal of experimental medicine 215, 3151-3164. PMID: 30498080
참고사항	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Flow CytoMetry

Flow-cytometry using APC anti-human CD275 antibody. U937 cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD275 monoclonal antibody (Catalog: HF564137, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

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