中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HY422023 | ||||||
|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||
| 응용 분야 | ELISA, WB, FCM, Stimulation | ||||||
| 숙주 종 | Human | ||||||
| 클론성 | Monoclonal | ||||||
| 이소타입 | IgG4, kappa | ||||||
| 클론 ID | TGN1412 | ||||||
| 발현 시스템 | Mammalian cells | ||||||
| 타겟 | CD28 | ||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||
| 순도 | >95% purity as determined by SDS-PAGE. | ||||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||||
| 등록번호 | P10747 | ||||||
| RRID | Anti-Human CD28 Antibody (TGN1412) (abinScience Cat# HY422023, RRID:AB_3729830) |
||||||
| 형태 | Liquid | ||||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||
| 제품 사용 정보 |
| ||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. | ||||||
| 대체 이름 | CD28 superagonist,CD28SA, TAB08 | ||||||
| 배경 | T-cell-specific surface glycoprotein CD28 is a ~25 kDa protein. Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis. Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells. 1. Gimmi, CD. et al. (1991) Proceedings of the National Academy of Sciences of the United States of America 88, 6575-9. PMID: 1650475 2. Raab, M. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 8891-5. PMID: 7568038 3. Skånland, SS. et al. (2014) The Biochemical journal 460, 399-410. PMID: 24665965 4. Collins, AV. et al. (2002) Immunity 17, 201-10. PMID: 12196291 5. Wu, H. et al. (2022) Structure (London, England : 1993) 30, 803-812.e5. PMID: 35397202 6. Kong, KF. et al. (2011) Nature immunology 12, 1105-12. PMID: 21964608 7. Blotta, MH. et al. (1996) Journal of immunology (Baltimore, Md. : 1950) 156, 3133-40. PMID: 8617933 | ||||||
| 참고사항 | For research use only. | ||||||
| Isotype Control | Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207) |
SDS-PAGE for Anti-Human CD28 Antibody (TGN1412)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
