Anti-Human CD301/CLEC10A Recombinant Antibody (49C11), PE (HV834127)

Name: Anti-Human CD301/CLEC10A Recombinant Antibody (49C11), PE
Brand: abinScience
SKU: HV834127
Price: 290 USD
Availability: InStock

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개요

카탈로그 번호	HV834127
종 반응성	Human
응용 분야	FCM
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG1, kappa
클론 ID	49C11
접합	PE
타겟	CD301, Macrophage lectin 2, C-type lectin domain family 10 member A, CLECSF13, C-type lectin superfamily member 14, CLEC10A, CLECSF14, HML
내독소 수준	Please contact with the lab for this information.
관련 제품	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), PE
등록번호	Q8IUN9
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Store at 4°C for 12 months. Protect from light. Do not freeze.
배경	C-type lectin domain family 10 member A (CD301/CLEC10A) is a ~35 kDa protein. C-type lectin receptor involved in recognition of N-acetylgalactosamine (GalNAc)-terminated glycans by myeloid antigen presenting cells (APCs). Binds in a Ca(2+)-dependent manner to alpha- and beta-linked GalNAc residues on glycoprotein and glycolipid antigens, including alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr also known as Tn and T antigens, LacdiNAc epitope GalNAcbeta1->4GlcNAc and its derivative GalNAcbeta1->4-(Fucalpha1->3)GlcNAc, O-linked core 5 and 6 glycans, and GM2 and GD2 gangliosides. Acts as a signaling receptor at the interface of APC-T cell interactions. On immature dendritic cells, recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and downregulates PTRPN/CD45 phosphatase activity with an impact on T cell activation threshold, cytokine production and proliferation. Modulates dendritic cell maturation toward a tolerogenic phenotype leading to generation of regulatory CD4-positive T cell subset with immune suppressive functions. _x005F_x000D_ _x005F_x000D_ 1. van Vliet, SJ. et al. (2005) International immunology 17, 661-9. PMID: 15802303 _x005F_x000D_ _x005F_x000D_ 2. van Vliet, SJ. et al. (2006) Nature immunology 7, 1200-8. PMID: 16998493 _x005F_x000D_ _x005F_x000D_ 3. van Vliet, SJ. et al. (2007) European journal of immunology 37, 2075-81. PMID: 17616966 _x005F_x000D_ _x005F_x000D_ 4. Li, D. et al. (2012) The Journal of experimental medicine 209, 109-21. PMID: 22213806 _x005F_x000D_ _x005F_x000D_ 5. Gabba, A. et al. (2021) Biochemistry 60, 1327-1336. PMID: 33724805 _x005F_x000D_ _x005F_x000D_ 6. Suzuki, N. et al. (1996) Journal of immunology (Baltimore, Md. : 1950) 156, 128-35. PMID: 8598452 _x005F_x000D_ _x005F_x000D_ 7. Mortezai, N. et al. (2013) Glycobiology 23, 844-52. PMID: 23507963
참고사항	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CD301/CLEC10A Recombinant Antibody (49C11), PE.pdf

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Anti-Human CD301/CLEC10A Recombinant Antibody (49C11), PE (HV834127)

개요

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