Anti-Human TIM-3 Recombinant Antibody (TSR-022), PE (HV029127)

Name: Anti-Human TIM-3 Recombinant Antibody (TSR-022), PE
Brand: abinScience
SKU: HV029127
Price: 290 USD
Availability: InStock

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HV029127
종 반응성	Human
응용 분야	FCM
숙주 종	Human
클론성	Monoclonal
이소타입	IgG4, kappa
클론 ID	TSR-022
접합	PE
타겟	CD366, HAVCR2, HAVcr-2, Hepatitis A virus cellular receptor 2, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIM-3, TIM3, TIMD-3, TIMD3
내독소 수준	Please contact with the lab for this information.
순도	>90% as determined by SDS-PAGE.
관련 제품	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), PE
등록번호	Q8TDQ0
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Store at 4°C for 12 months. Protect from light. Do not freeze.
배경	Hepatitis A virus cellular receptor 2 (CD366/TIM-3) is a ~33 kDa protein. Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. _x005F_x000D_ _x005F_x000D_ 1. Gorman, JV. et al. (2014) Immunologic research 59, 56-65. PMID: 24825777 _x005F_x000D_ _x005F_x000D_ 2. Monney, L. et al. (2002) Nature 415, 536-41. PMID: 11823861 _x005F_x000D_ _x005F_x000D_ 3. Sánchez-Fueyo, A. et al. (2003) Nature immunology 4, 1093-101. PMID: 14556005 _x005F_x000D_ _x005F_x000D_ 4. Clayton, KL. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 782-91. PMID: 24337741 _x005F_x000D_ _x005F_x000D_ 5. Tomkowicz, B. et al. (2015) PloS one 10, e0140694. PMID: 26492563 _x005F_x000D_ _x005F_x000D_ 6. Gautron, AS. et al. (2014) European journal of immunology 44, 2703-2711. PMID: 24838857 _x005F_x000D_ _x005F_x000D_ 7. Zhu, C. et al. (2005) Nature immunology 6, 1245-52. PMID: 16286920 _x005F_x000D_ _x005F_x000D_ 8. Leitner, J. et al. (2013) PLoS pathogens 9, e1003253. PMID: 23555261 _x005F_x000D_ _x005F_x000D_ 9. Gleason, MK. et al. (2012) Blood 119, 3064-72. PMID: 22323453
참고사항	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.