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| 카탈로그 번호 | HY323137 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | FCM |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 클론 ID | LM609 |
| 접합 | APC |
| 타겟 | GPIIIa, Integrin beta-3, CD61, ITGB3, Platelet membrane glycoprotein IIIa, GP3A |
| 내독소 수준 | Please contact with the lab for this information. |
| 관련 제품 | Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC |
| 등록번호 | P05106 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 배경 | Integrin beta-3 (Integrin αVβ3 (CD51/ITGAV & CD61) is a ~87 kDa protein. Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. 1. Si-Tahar, M. et al. (1997) The Journal of biological chemistry 272, 11636-47. PMID: 9111081 2. Fujita, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 5809-19. PMID: 23125415 3. Fujita, M. et al. (2014) PloS one 9, e96372. PMID: 24789099 4. Ieguchi, K. et al. (2010) The Journal of biological chemistry 285, 31388-98. PMID: 20682778 5. Mori, S. et al. (2008) The Journal of biological chemistry 283, 18066-75. PMID: 18441324 6. Mori, S. et al. (2017) Bioscience reports 37. PMID: 28302677 7. Saegusa, J. et al. (2009) The Journal of biological chemistry 284, 24106-14. PMID: 19578119 8. Cedano Prieto, DM. et al. (2017) PloS one 12, e0184285. PMID: 28873464 9. Takada, YK. et al. (2017) The Journal of biological chemistry 292, 20067-20075. PMID: 29030430 10. Saegusa, J. et al. (2008) The Journal of biological chemistry 283, 26107-15. PMID: 18635536 |
| 참고사항 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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