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| 카탈로그 번호 | HB064107 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | FCM |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 클론 ID | SAA0039 |
| 타겟 | CD88, C5AR1, C5R1, C5AR, C5a-R, C5aR, C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P21730 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | C5a anaphylatoxin chemotactic receptor 1 (CD88/C5AR1) is a ~39 kDa protein. Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. 1. Christophe, T. et al. (2000) The Journal of biological chemistry 275, 1656-64. PMID: 10636859 2. Postma, B. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 172, 6994-7001. PMID: 15153520 3. Gerard, NP. et al. (1991) Nature 349, 614-7. PMID: 1847994 4. Robertson, N. et al. (2018) Nature 553, 111-114. PMID: 29300009 5. Feng, Y. et al. (2023) Cell research 33, 312-324. PMID: 36806352 6. Monk, PN. et al. (1995) The Journal of biological chemistry 270, 16625-9. PMID: 7622471 7. DeMartino, JA. et al. (1994) The Journal of biological chemistry 269, 14446-50. PMID: 8182049 8. Chen, Z. et al. (1998) The Journal of biological chemistry 273, 10411-9. PMID: 9553099 9. Yadav, MK. et al. (2023) Cell 186, 4956-4973.e21. PMID: 37852260 |
| 참고사항 | For research use only. |
SEC-HPLC detection for Anti-Human CD88/C5AR1 Antibody (ABS1062).
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