Anti-Human CD98/SLC3A2 Recombinant Antibody (Ab110), APC (HY415137)

Name: Anti-Human CD98/SLC3A2 Recombinant Antibody (Ab110), APC
Brand: abinScience
SKU: HY415137
Price: 290 USD
Availability: InStock

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개요
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참고 문헌
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개요

카탈로그 번호	HY415137
종 반응성	Human
응용 분야	FCM
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG1, kappa
클론 ID	Ab110
접합	APC
타겟	SLC3A2, 4F2hc, Lymphocyte activation antigen 4F2 large subunit, CD98, 4F2 cell-surface antigen heavy chain, Solute carrier family 3 member 2, MDU1, 4F2 heavy chain antigen
내독소 수준	Please contact with the lab for this information.
관련 제품	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
등록번호	P08195
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Store at 4°C for 12 months. Protect from light. Do not freeze.
배경	Amino acid transporter heavy chain SLC3A2 (CD98) is a ~57 kDa protein. Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters. Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids. Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane. 1. Rossier, G. et al. (1999) The Journal of biological chemistry 274, 34948-54. PMID: 10574970 2. Bröer, A. et al. (2000) The Biochemical journal 349 Pt 3, 787-95. PMID: 10903140 3. Yanagida, O. et al. (2001) Biochimica et biophysica acta 1514, 291-302. PMID: 11557028 4. Yan, R. et al. (2019) Nature 568, 127-130. PMID: 30867591 5. Yan, R. et al. (2020) Cell discovery 6, 82. PMID: 33298890 6. Yan, R. et al. (2021) Cell discovery 7, 16. PMID: 33758168 7. Parker, JL. et al. (2021) Nature communications 12, 7147. PMID: 34880232 8. Mastroberardino, L. et al. (1998) Nature 395, 288-91. PMID: 9751058 9. Torrents, D. et al. (1998) The Journal of biological chemistry 273, 32437-45. PMID: 9829974 10. Pfeiffer, R. et al. (1999) The EMBO journal 18, 49-57. PMID: 9878049
참고사항	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Flow CytoMetry

Flow-cytometry using APC anti-human CD98 antibody. Hela cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD98 monoclonal antibody (Catalog: HY415137, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

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