Anti-Human CDK9 Polyclonal Antibody (HW357024)

Name: Anti-Human CDK9 Polyclonal Antibody
Brand: abinScience
SKU: HW357024
Price: 96 USD
Availability: InStock

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HW357024

설명

Anti-Human CDK9 Polyclonal Antibody (HW357024) is a rabbit polyclonal antibody detecting CDK9 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Danio rerio, Human, Xenopus laevis, and Gallus gallus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CDK9 (Asp104-Phe315).

타겟

CDK9

정제

Purified by antigen affinity column.

등록번호

P50750

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

대체 이름

Cyclin-dependent kinase 9, 2.7.11.22, 2.7.11.23, C-2K, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, Tat-associated kinase complex catalytic subunit, CDK9, CDC2L4, TAK

배경

Cyclin-dependent kinase 9 (CDK9) is a ~42 kDa protein. Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELFE. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g.

1. Fu, TJ. et al. (1999) The Journal of biological chemistry 274, 34527-30. PMID: 10574912

2. Ivanov, D. et al. (2000) Molecular and cellular biology 20, 2970-83. PMID: 10757782

3. Kim, JB. et al. (2001) The Journal of biological chemistry 276, 12317-23. PMID: 11145967

4. Lavoie, SB. et al. (2001) Journal of molecular biology 312, 675-85. PMID: 11575923

5. Bourgeois, CF. et al. (2002) Molecular and cellular biology 22, 1079-93. PMID: 11809800

6. Lin, X. et al. (2002) The Journal of biological chemistry 277, 16873-8. PMID: 11884399

7. Fujinaga, K. et al. (2004) Molecular and cellular biology 24, 787-95. PMID: 14701750

8. Jang, MK. et al. (2005) Molecular cell 19, 523-34. PMID: 16109376

9. Yang, Z. et al. (2005) Molecular cell 19, 535-45. PMID: 16109377

10. Yu, DS. et al. (2010) EMBO reports 11, 876-82. PMID: 20930849

참고사항

For research use only.

이미지

Western blot

Western blot analysis was performed using anti-CDK9 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse lung lysate
Lane 2: Rat brain lysate
Lane 3: Rat lung lysate