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| 카탈로그 번호 | HP462014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human CEP135 (Asn63-Pro188). | ||||||||
| 타겟 | KIAA0635, Centrosomal protein of 135 kDa, Centrosomal protein 4, Cep135, CEP4, CEP135 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q66GS9 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Centrosomal protein of 135 kDa (CEP135) is a ~133 kDa protein. Centrosomal microtubule-binding protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. 1. Kraatz, S. et al. (2016) Structure (London, England : 1993) 24, 1358-1371. PMID: 27477386 2. Chang, CW. et al. (2016) Journal of cell science 129, 2501-13. PMID: 27185865 | ||||||||
| 참고사항 | For research use only. |
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