Anti-Human CHRNB4 Polyclonal Antibody (HB165014)

Name: Anti-Human CHRNB4 Polyclonal Antibody
Brand: abinScience
SKU: HB165014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HB165014

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CHRNB4 (Arg22-Lys231).

타겟

CHRNB4, Neuronal acetylcholine receptor subunit beta-4

정제

Purified by antigen affinity column.

등록번호

P30926

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Neuronal acetylcholine receptor subunit beta-4 (CHRNB4) is a ~56 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNB4 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3 and CHRNA4, as well as CHRNA5 and CHRNB3 as accesory subunits. CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor.

1. Kuryatov, A. et al. (2011) Molecular pharmacology 79, 119-25. PMID: 20881005

2. Gharpure, A. et al. (2019) Neuron 104, 501-511.e6. PMID: 31488329

3. Wang, F. et al. (1996) The Journal of biological chemistry 271, 17656-65. PMID: 8663494

4. Elliott, KJ. et al. (1996) Journal of molecular neuroscience : MN 7, 217-28. PMID: 8906617

5. Gerzanich, V. et al. (1997) Molecular pharmacology 51, 320-7. PMID: 9203638

6. Boorman, JP. et al. (2000) The Journal of physiology 529 Pt 3, 565-77. PMID: 11118490

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human CHRNB4 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human CHRNB4 Polyclonal Antibody (HB165014)

개요

이미지

참고 문헌

데이터시트

SDS

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