Anti-Human CIP2A Polyclonal Antibody (HV712014)

Name: Anti-Human CIP2A Polyclonal Antibody
Brand: abinScience
SKU: HV712014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HV712014

설명

Anti-Human CIP2A Polyclonal Antibody (HV712014) is a rabbit polyclonal antibody detecting Protein CIP2A. Suitable for Human.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CIP2A (Asp2-Glu560).

타겟

CIP2A, Cancerous inhibitor of PP2A, KIAA1524, Protein CIP2A, p90 autoantigen

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q8TCG1

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Protein CIP2A is a ~102 kDa protein. Acts as an inhibitor of protein phosphatase PP2A. Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies. Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei. Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss.

1. Junttila, MR. et al. (2007) Cell 130, 51-62. PMID: 17632056

2. Adam, S. et al. (2021) Nature cancer 2, 1357-1371. PMID: 35121901

3. De Marco Zompit, M. et al. (2022) Nature communications 13, 4143. PMID: 35842428

4. Lin, YF. et al. (2023) Nature 618, 1041-1048. PMID: 37165191

5. Trivedi, P. et al. (2023) Nature 618, 1049-1056. PMID: 37316668

참고사항

For research use only

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참고 문헌

데이터시트

Anti-Human CIP2A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human CIP2A Polyclonal Antibody (HV712014)

개요

이미지

참고 문헌

데이터시트

SDS

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