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| 카탈로그 번호 | HA681014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human CLCNKA Polyclonal Antibody (HA681014) is a rabbit polyclonal antibody detecting Chloride channel protein ClC-Ka; Chloride channel Ka; ClC-K1; CLCNKA in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human CLCNKA (Ala507-Lys687). | ||||||||
| 타겟 | Chloride channel protein ClC-Ka; Chloride channel Ka; ClC-K1; CLCNKA | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P51800, P51801 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Chloride channel protein ClC-Ka (CLCNKA) is a ~75 kDa protein. Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide. Forms a homodimeric channel where each subunit has its own ion conduction pathway. May conduct double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain and functional switch to the ion conducting state. CLCNKA:BSND channels display mostly a linear current-voltage relationship with fast gating at negative potentials. 1. Estévez, R. et al. (2001) Nature 414, 558-61. PMID: 11734858 2. Waldegger, S. et al. (2002) Pflugers Archiv : European journal of physiology 444, 411-8. PMID: 12111250 3. Nozu, K. et al. (2008) Journal of medical genetics 45, 182-6. PMID: 18310267 4. Janssen, AG. et al. (2009) Journal of the American Society of Nephrology : JASN 20, 145-53. PMID: 18776122 5. Riazuddin, S. et al. (2009) American journal of human genetics 85, 273-80. PMID: 19646679 6. Fischer, M. et al. (2010) Journal of the American Society of Nephrology : JASN 21, 1281-9. PMID: 20538786 | ||||||||
| 참고사항 | For research use only |
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