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| 카탈로그 번호 | HA366023 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA, FACS, Functional assay | ||||
| 숙주 종 | Human | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG1, kappa | ||||
| 클론 ID | BDC-3042 | ||||
| 타겟 | C-type lectin domain family 6 member A, C-type lectin superfamily member 10, CLEC6A, CLECSF10, DC-associated C-type lectin 2, DECTIN2, Dectin-2, Dendritic cell-associated C-type lectin 2 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q6EIG7 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | C-type lectin domain family 6 member A (CLEC6A/Dectin-2) is a ~23 kDa protein. Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. 1. Zhu, LL. et al. (2013) Immunity 39, 324-34. PMID: 23911656 2. Feinberg, H. et al. (2017) The Journal of biological chemistry 292, 13402-13414. PMID: 28652405 | ||||
| 참고사항 | For research use only |
SDS-PAGE for Anti-Human CLEC6A/Dectin-2 Antibody (BDC-3042)
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