中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HD609014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human CLNS1A Polyclonal Antibody (HD609014) is a rabbit polyclonal antibody detecting CLNS1A. Suitable for Human.
|
||||||||
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human CLNS1A (Met1-Leu135). | ||||||||
| 타겟 | CLCI, CLNS1A, Chloride channel, nucleotide sensitive 1A, Chloride conductance regulatory protein ICln, Chloride ion current inducer protein, ClCI, I(Cln), ICLN, Methylosome subunit pICln, Reticulocyte pICln | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P54105 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 배경 | Methylosome subunit pICln (CLNS1A) is a ~26 kDa protein. Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. 1. Pu, WT. et al. (1999) Molecular and cellular biology 19, 4113-20. PMID: 10330151 2. Friesen, WJ. et al. (2001) Molecular and cellular biology 21, 8289-300. PMID: 11713266 3. Chari, A. et al. (2008) Cell 135, 497-509. PMID: 18984161 4. Guderian, G. et al. (2011) The Journal of biological chemistry 286, 1976-86. PMID: 21081503 | ||||||||
| 참고사항 | For research use only |
Western blot analysis was performed using anti-CLNS1A polyclonal antibody at 1ug/mL on various samples.
Lane 1: HT-29 cell lysate
Lane 2: 293T cell lysate
Lane 3: Hela cell lysate
문의하기
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
