中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HD496013 |
|---|---|
| 설명 |
Anti-Human CMTM6 Nanobody (SAA2685) [SAA2685] (HD496013) is a alpaca monoclonal antibody detecting CMTM6 in ELISA. Suitable for Human.
|
| 종 반응성 | Human |
| 응용 분야 | ELISA |
| 숙주 종 | Alpaca |
| 클론성 | Monoclonal |
| 이소타입 | VHH-8His |
| 클론 ID | SAA2685 |
| 타겟 | CKLF-like MARVEL transmembrane domain-containing protein 6, CKLFSF6, CMTM6, Chemokine-like factor superfamily member 6 |
| 내독소 수준 | <10 EU/mg |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | Q9NX76 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 배경 | CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) is a ~20 kDa protein. Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. |
| 참고사항 | For research use only |
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
