中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HT054014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human COX7A2L Polyclonal Antibody (HT054014) is a rabbit polyclonal antibody detecting COX7A2L in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.
Highlights
|
||||||||
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human COX7A2L (Met1-Lys114). | ||||||||
| 타겟 | EB1, COX7RP, Cytochrome c oxidase subunit 7A-related protein, mitochondrial, COX7A2L, COX7a-related protein, Cytochrome c oxidase subunit VIIa-related protein, COX7AR | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O14548 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Cytochrome c oxidase subunit 7A2-like, mitochondrial (COX7A2L) is a ~12 kDa protein. Assembly factor that mediates the formation of some mitochondrial respiratory supercomplexes (respirasomes), thereby promoting oxidative phosphorylation and energy metabolism. Acts as a molecular adapter that associates with both mitochondrial respiratory complexes III (CIII) and IV (CIV), promoting their association. Mediates the formation of various mitochondrial respiratory supercomplexes, such as MCIII(2)IV(2), composed of two CIII and two CIV, and the CS-respirasome (MCI(1)III(2)IV(2)), composed of one CI, two CIII and two CIV. Not involved in the formation of the canonical respirasome (MCI(1)III(2)IV(1)), composed of one CI, two CIII and one CIV. The formation of different respirasomes is important for cell adaptation to oxygen conditions and prevent metabolic exhaustion: supercomplexes mediated by COX7A2L/SCAF1 are required to maintain oxidative phosphorylation upon low oxygen conditions and promote metabolic rewiring toward glycolysis. 1. Pérez-Pérez, R. et al. (2016) Cell reports 16, 2387-98. PMID: 27545886 2. Lobo-Jarne, T. et al. (2018) Cell reports 25, 1786-1799.e4. PMID: 30428348 3. Fernández-Vizarra, E. et al. (2021) Biochimica et biophysica acta. Bioenergetics 1862, 148414. PMID: 33727070 4. Fernández-Vizarra, E. et al. (2022) Cell metabolism 34, 1792-1808.e6. PMID: 36198313 | ||||||||
| 참고사항 | For research use only. |
문의하기
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
