Anti-Human CRCP Polyclonal Antibody (HF859014)

Name: Anti-Human CRCP Polyclonal Antibody
Brand: abinScience
SKU: HF859014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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개요

카탈로그 번호

HF859014

설명

Anti-Human CRCP Polyclonal Antibody (HF859014) is a rabbit polyclonal antibody detecting CRCP in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CRCP (Ser12-Ala148).

타겟

CGRPRCP, HsC17, Calcitonin gene-related peptide-receptor component protein, CGRP-RCP, CRCP, RNA polymerase III subunit C9, DNA-directed RNA polymerase III subunit RPC9, CGRP-receptor component protein

정제

Purified by antigen affinity column.

등록번호

O75575

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

DNA-directed RNA polymerase III subunit RPC9 (CRCP) is a ~16 kDa protein. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response.

1. Canella, D. et al. (2010) Genome research 20, 710-21. PMID: 20413673

2. Girbig, M. et al. (2021) Nature structural & molecular biology 28, 210-219. PMID: 33558764

3. Hou, H. et al. (2021) Nature communications 12, 6135. PMID: 34675218

4. Wang, Q. et al. (2021) Nature structural & molecular biology 28, 220-227. PMID: 33558766

5. Ablasser, A. et al. (2009) Nature immunology 10, 1065-72. PMID: 19609254

6. Chiu, YH. et al. (2009) Cell 138, 576-91. PMID: 19631370

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human CRCP Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human CRCP Polyclonal Antibody (HF859014)

개요

이미지

참고 문헌

데이터시트

SDS