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| 카탈로그 번호 | HW518033 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-Human CTNNB1 Nanobody (SAA1410) [SAA1410] (HW518033) is a alpaca monoclonal antibody detecting Human CTNNB1 in ELISA. Suitable for Human.
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| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Alpaca | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | VHH-His | ||||
| 클론 ID | SAA1410 | ||||
| 타겟 | BC2 peptide-tag, BC2e-tag, PDRKAAVSHWQQ | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Purified by Nickel column. | ||||
| 등록번호 | P35222 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Catenin beta-1 (CTNNB1) is a ~85 kDa protein. Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Also acts as a coactivator for other transcription factors, such as NR5A2. Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes. 1. Lillehoj, EP. et al. (2007) Biochimica et biophysica acta 1773, 1028-38. PMID: 17524503 2. Weiske, J. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 20344-9. PMID: 18077326 3. Bahmanyar, S. et al. (2008) Genes & development 22, 91-105. PMID: 18086858 4. Li, H. et al. (2009) The Journal of biological chemistry 284, 2012-22. PMID: 18957423 5. Fiset, A. et al. (2011) Cellular signalling 23, 911-9. PMID: 21262353 6. Satow, R. et al. (2012) Gastroenterology 142, 572-81. PMID: 22155184 7. Genovese, G. et al. (2012) Cell cycle (Georgetown, Tex.) 11, 2206-15. PMID: 22647378 8. Yu, Y. et al. (2012) EMBO reports 13, 750-8. PMID: 22699938 10. Park, J. et al. (2018) Stem cell reports 11, 115-127. PMID: 29910125 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human CTNNB1 Nanobody (SAA1410)
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