Anti-Human CX3CR1 Polyclonal Antibody (HW331014)

Name: Anti-Human CX3CR1 Polyclonal Antibody
Brand: abinScience
SKU: HW331014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HW331014

설명

Anti-Human CX3CR1 Polyclonal Antibody (HW331014) is a rabbit polyclonal antibody detecting CX3CR1 in WB, IHC, ELISA. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

WB, IHC, ELISA

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CX3CR1 (Asp2-Thr31&Glu298-Leu355).

타겟

CX3CR1

내독소 수준

Please contact with the lab for this information.

순도

>90% as determined by SDS-PAGE.

정제

Purified by antigen affinity column.

등록번호

P49238

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

대체 이름

CX3C chemokine receptor 1, C-X3-C CKR-1, CX3CR1, Beta chemokine receptor-like 1, CMK-BRL-1, CMK-BRL1, Fractalkine receptor, G-protein coupled receptor 13, V28, CX3CR1, CMKBRL1, GPR13

배경

CX3C chemokine receptor 1 (CX3CR1) is a ~40 kDa protein. Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. CX3CR1-CX3CL1 signaling mediates cell migratory functions. Responsible for the recruitment of natural killer (NK) cells to inflamed tissues. Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival. Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung.

1. Nishimura, M. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 6173-80. PMID: 12055230

2. Fujita, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 5809-19. PMID: 23125415

3. Imai, T. et al. (1997) Cell 91, 521-30. PMID: 9390561

4. Fong, AM. et al. (1998) The Journal of experimental medicine 188, 1413-9. PMID: 9782118

5. Lucas, AD. et al. (2003) Circulation 108, 2498-504. PMID: 14581400

6. Landsman, L. et al. (2009) Blood 113, 963-72. PMID: 18971423

7. Leonardi, I. et al. (2018) Science (New York, N.Y.) 359, 232-236. PMID: 29326275

8. Nakayama, T. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 185, 6472-9. PMID: 20974991

참고사항

For research use only.

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