Anti-Human CXCL4/PF4 Recombinant Antibody (U.Penn. patent anti-PF4) (HY443043)

Name: Anti-Human CXCL4/PF4 Recombinant Antibody (U.Penn. patent anti-PF4)
Brand: abinScience
SKU: HY443043
Price: 126 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD): --

사양:

20ug
50ug
100ug
1mg

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HY443043

설명

Anti-Human CXCL4/PF4 Recombinant Antibody (U.Penn. patent anti-PF4) (HY443043) is a mouse monoclonal antibody detecting CXCL4/PF4 in ELISA, FCM, Functional. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, FCM, Functional

숙주 종

Mouse

클론성

Monoclonal

이소타입

IgG1, kappa

클론 ID

U.Penn. patent anti-PF4

타겟

Platelet factor 4, PF-4, C-X-C motif chemokine 4, Iroplact, Oncostatin-A, Platelet factor 4 short form, Endothelial cell growth inhibitor, PF4, CXCL4, SCYB4

내독소 수준

< 10 EU/mg as determined by LAL method.

순도

>95% as determined by SDS-PAGE.

정제

Protein A/G purified from cell culture supernatant.

등록번호

P02776

형태

Liquid

저장 완충액

0.01M PBS pH 7.4

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:2000-1:20000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Platelet factor 4 (CXCL4/PF) is a ~10 kDa protein. Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation. Acts via different functional receptors including CCR1, CXCR3A or CXCR3B. Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence.

1. Fox, JM. et al. (2018) Scientific reports 8, 9466. PMID: 29930254

2. Lecomte-Raclet, L. et al. (1998) Blood 91, 2772-80. PMID: 9531587

3. Mueller, A. et al. (2008) Journal of leukocyte biology 83, 875-82. PMID: 18174362

4. Van Raemdonck, K. et al. (2014) Angiogenesis 17, 631-40. PMID: 24469069

5. Yang, C. et al. (2022) Nature communications 13, 3426. PMID: 35701499

6. Affandi, AJ. et al. (2022) Cell reports 38, 110189. PMID: 34986347

7. Dudek, AZ. et al. (1997) The Journal of biological chemistry 272, 31785-92. PMID: 9395524

참고사항

For research use only.

Isotype Control

Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

이미지

SDS-PAGE

SDS-PAGE for Anti-Human CXCL4/PF4 Antibody (U.Penn. patent anti-PF4)

참고 문헌

데이터시트

Anti-Human CXCL4/PF4 Recombinant Antibody (U.Penn. patent anti-PF4).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human CXCL4/PF4 Recombinant Antibody (U.Penn. patent anti-PF4) (HY443043)

개요

이미지

참고 문헌

데이터시트

SDS