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| 카탈로그 번호 | HY448107 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | FCM, IP, WB |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG2a, kappa |
| 클론 ID | SAA0847 |
| 타겟 | Cytochrome b558 subunit beta, Cytochrome b(558) subunit beta, Heme-binding membrane glycoprotein gp91phox, Neutrophil cytochrome b 91 kDa polypeptide, gp91-phox, NOX2, Cytochrome b-245 heavy chain, p22 phagocyte B-cytochrome, Superoxide-generating NADPH oxidase heavy chain subunit, gp91-1, NADPH oxidase 2, CYBB, CGD91-phox |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P04839 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.09% Sodium azide. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | NADPH oxidase 2 (CYBB/NOX2) is a ~65 kDa protein. Catalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (Probable). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. NADPH oxidase complex assembly is impaired through interaction with NRROS. 1. Bionda, C. et al. (2004) Human genetics 115, 418-27. PMID: 15338276 2. Noreng, S. et al. (2022) Nature communications 13, 6079. PMID: 36241643 3. Liu, R. et al. (2022) eLife 11. PMID: 36413210 4. Liu, X. et al. (2024) Nature 627, 189-195. PMID: 38355798 5. Raad, H. et al. (2009) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23, 1011-22. PMID: 19028840 |
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human CYBB/NOX2 Antibody (SAA0847)
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