Anti-Human CYLD Polyclonal Antibody (HV742014)

Name: Anti-Human CYLD Polyclonal Antibody
Brand: abinScience
SKU: HV742014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD): --

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HV742014

설명

Anti-Human CYLD Polyclonal Antibody (HV742014) is a rabbit polyclonal antibody detecting CYLD. Suitable for Rat, Human, and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CYLD (Asn553-Lys956).

타겟

CYLD, CYLD1, Deubiquitinating enzyme CYLD, EC:3.4.19.12, KIAA0849, Ubiquitin carboxyl-terminal hydrolase CYLD, Ubiquitin thioesterase CYLD, Ubiquitin-specific-processing protease CYLD

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q9NQC7

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Ubiquitin carboxyl-terminal hydrolase CYLD is a ~107 kDa protein. Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-induced necroptosis. Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules.

1. Komander, D. et al. (2008) Molecular cell 29, 451-64. PMID: 18313383

2. Friedman, CS. et al. (2008) EMBO reports 9, 930-6. PMID: 18636086

3. Draber, P. et al. (2015) Cell reports 13, 2258-72. PMID: 26670046

4. Hrdinka, M. et al. (2016) Cell reports 14, 2846-58. PMID: 26997266

5. Schlicher, L. et al. (2016) EMBO reports 17, 1485-1497. PMID: 27458237

6. Elliott, PR. et al. (2016) Molecular cell 63, 990-1005. PMID: 27591049

7. Ohtake, F. et al. (2016) Molecular cell 64, 251-266. PMID: 27746020

8. Ji, YX. et al. (2018) Nature medicine 24, 213-223. PMID: 29291351

9. Dobson-Stone, C. et al. (2020) Brain : a journal of neurology 143, 783-799. PMID: 32185393

10. Trompouki, E. et al. (2003) Nature 424, 793-6. PMID: 12917689

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human CYLD Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human CYLD Polyclonal Antibody (HV742014)

개요

이미지

참고 문헌

데이터시트

SDS