Anti-Human DNAJB2 Polyclonal Antibody (HB700014)

Name: Anti-Human DNAJB2 Polyclonal Antibody
Brand: abinScience
SKU: HB700014
Price: 96 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HB700014

설명

Anti-Human DNAJB2 Polyclonal Antibody (HB700014) is a rabbit polyclonal antibody detecting DNAJB2 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human DNAJB2 (Ala2-Gly91).

타겟

HSJ-1, Heat shock protein J1, DNAJB2, Heat shock 40 kDa protein 3, DnaJ homolog subfamily B member 2, HSPF3, HSJ1

정제

Purified by antigen affinity column.

등록번호

P25686

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

DnaJ homolog subfamily B member 2 (DNAJB2) is a ~35 kDa protein. Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins.

1. Gao, XC. et al. (2012) The Journal of biological chemistry 287, 6044-52. PMID: 22219199

2. Cheetham, ME. et al. (1994) European journal of biochemistry 226, 99-107. PMID: 7957263

3. Westhoff, B. et al. (2005) Current biology : CB 15, 1058-64. PMID: 15936278

4. Gao, XC. et al. (2011) PloS one 6, e19763. PMID: 21625540

5. Chapple, JP. et al. (2003) The Journal of biological chemistry 278, 19087-94. PMID: 12754272

6. Rose, JM. et al. (2011) Human molecular genetics 20, 16-27. PMID: 20889486

7. Meimaridou, E. et al. (2011) Molecular endocrinology (Baltimore, Md.) 25, 1650-60. PMID: 21719532

8. Labbadia, J. et al. (2012) Brain : a journal of neurology 135, 1180-96. PMID: 22396390

9. Novoselov, SS. et al. (2013) PloS one 8, e73944. PMID: 24023695

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human DNAJB2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human DNAJB2 Polyclonal Antibody (HB700014)

개요

이미지

참고 문헌

데이터시트

SDS