

| 카탈로그 번호 | HV184014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human DNAJC2 Polyclonal Antibody (HV184014) is a rabbit polyclonal antibody detecting DNAJC2. Suitable for Human, Mouse, and Rat.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human DNAJC2 (Lys442-Lys621). | ||||||||
| 타겟 | DNAJC2, DnaJ homolog subfamily C member 2, DnaJ homolog subfamily C member 2, N-terminally processed, M-phase phosphoprotein 11, MPHOSPH11, MPP11, ZRF1, Zuotin-related factor 1 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q99543 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | DnaJ homolog subfamily C member 2 (DNAJC2) is a ~71 kDa protein. Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. | ||||||||
| 참고사항 | For research use only |

Western blot analysis was performed using anti-DNAJC2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Caco2 cell lysate
Lane 2: HT-29 cell lysate
Lane 3: Hela cell lysate
Lane 4: HepG2 cell lysate
Lane 5: K562 cell lysate
Lane 6: PC-3 cell lysate
Lane 7: NIH3T3 cell lysate


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