Anti-Human Desmoglein-2 Polyclonal Antibody (HC461014)

Name: Anti-Human Desmoglein-2 Polyclonal Antibody
Brand: abinScience
SKU: HC461014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD): --

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HC461014

설명

Anti-Human Desmoglein-2 Polyclonal Antibody (HC461014) is a rabbit polyclonal antibody detecting Desmoglein-2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human DSG2 (Lys275-Val533).

타겟

CDHF5, HDGC, Desmoglein-2, DSG2, Cadherin family member 5

내독소 수준

Please contact with the lab for this information.

순도

>95% as determined by SDS-PAGE.

정제

Purified by antigen affinity column.

등록번호

Q14126

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Desmoglein-2 (DSG2) is a ~122 kDa protein. A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development. Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes. Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells.

1. Cirillo, N. et al. (2008) Journal of cellular biochemistry 103, 598-606. PMID: 17559062

2. Xu, T. et al. (2024) Kidney international 105, 1035-1048. PMID: 38395410

3. Park, J. et al. (2018) Stem cell reports 11, 115-127. PMID: 29910125

4. Ebert, LM. et al. (2016) Angiogenesis 19, 463-86. PMID: 27338829

5. Overmiller, AM. et al. (2016) Oncotarget 7, 37536-37555. PMID: 26918609

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human Desmoglein-2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human Desmoglein-2 Polyclonal Antibody (HC461014)

개요

이미지

참고 문헌

데이터시트

SDS