Anti-Human EHMT2 Polyclonal Antibody (HP382014)

Name: Anti-Human EHMT2 Polyclonal Antibody
Brand: abinScience
SKU: HP382014
Price: 168 USD
Availability: InStock

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개요

카탈로그 번호

HP382014

설명

Anti-Human EHMT2 Polyclonal Antibody (HP382014) is a rabbit polyclonal antibody detecting EHMT2 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human EHMT2 (Gly626-Thr918).

타겟

Histone H3-K9 methyltransferase 3, Histone-lysine N-methyltransferase EHMT2, BAT8, KMT1C, EHMT2, Euchromatic histone-lysine N-methyltransferase 2, H3-K9-HMTase 3, G9A, Lysine N-methyltransferase 1C, C6orf30, Protein G9a, HLA-B-associated transcript 8, NG36

정제

Purified by antigen affinity column.

등록번호

Q96KQ7

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Histone-lysine N-methyltransferase EHMT2 is a ~132 kDa protein. Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently.

1. Tachibana, M. et al. (2001) The Journal of biological chemistry 276, 25309-17. PMID: 11316813

2. Wu, H. et al. (2010) PloS one 5, e8570. PMID: 20084102

3. Yu, Y. et al. (2012) Molecular cell 46, 7-17. PMID: 22387026

4. Trojer, P. et al. (2009) The Journal of biological chemistry 284, 8395-405. PMID: 19144645

5. Huang, J. et al. (2010) The Journal of biological chemistry 285, 9636-9641. PMID: 20118233

6. Rathert, P. et al. (2008) Nature chemical biology 4, 344-6. PMID: 18438403

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human EHMT2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human EHMT2 Polyclonal Antibody (HP382014)

개요

이미지

참고 문헌

데이터시트

SDS