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| 카탈로그 번호 | HC232014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human EIF3A Polyclonal Antibody (HC232014) is a rabbit polyclonal antibody detecting EIF3A. Suitable for Rat, Mouse, and Human.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human EIF3A (Met1-Arg520). | ||||||||
| 타겟 | EIF3A, EIF3S10, Eukaryotic translation initiation factor 3 subunit 10, Eukaryotic translation initiation factor 3 subunit A, KIAA0139, eIF-3-theta, eIF3 p167, eIF3 p180, eIF3 p185, eIF3a | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q14152 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | Eukaryotic translation initiation factor 3 subunit A (EIF3A) is a ~166 kDa protein. RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. 1. Masutani, M. et al. (2007) The EMBO journal 26, 3373-83. PMID: 17581632 2. Lee, AS. et al. (2015) Nature 522, 111-4. PMID: 25849773 3. Lin, L. et al. (2001) Journal of cellular biochemistry 80, 483-90. PMID: 11169732 4. Lee, AS. et al. (2016) Nature 536, 96-9. PMID: 27462815 | ||||||||
| 참고사항 | For research use only |
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