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| 카탈로그 번호 | HC225014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human EMC2 Polyclonal Antibody (HC225014) is a rabbit polyclonal antibody detecting EMC2. Suitable for Rat, Mouse, and Human.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human EMC2 (Met1-Ser297). | ||||||||
| 타겟 | EMC2, ER membrane protein complex subunit 2, KIAA0103, TPR repeat protein 35, TTC35, Tetratricopeptide repeat protein 35 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q15006 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | ER membrane protein complex subunit 2 (EMC2) is a ~34 kDa protein. Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. 1. Guna, A. et al. (2018) Science (New York, N.Y.) 359, 470-473. PMID: 29242231 2. Shurtleff, MJ. et al. (2018) eLife 7. PMID: 29809151 3. Chitwood, PJ. et al. (2018) Cell 175, 1507-1519.e16. PMID: 30415835 4. Pleiner, T. et al. (2020) Science (New York, N.Y.) 369, 433-436. PMID: 32439656 5. O'Donnell, JP. et al. (2020) eLife 9. PMID: 32459176 6. Pleiner, T. et al. (2021) Molecular cell 81, 2693-2704.e12. PMID: 33964204 | ||||||||
| 참고사항 | For research use only |
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