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| 카탈로그 번호 | HB116207 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | FCM |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG2, lambda |
| 클론 ID | SAA0123 |
| 타겟 | ERBB3, HER3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, Receptor tyrosine-protein kinase erbB-3 |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P21860 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | Receptor tyrosine-protein kinase erbB-3 (ERBB3/HER3) is a ~148 kDa protein. Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. 1. Ieguchi, K. et al. (2010) The Journal of biological chemistry 285, 31388-98. PMID: 20682778 2. Kinugasa, Y. et al. (2004) Biochemical and biophysical research communications 321, 1045-9. PMID: 15358134 3. Braunstein, EM. et al. (2016) Leukemia 30, 2242-2245. PMID: 27416908 |
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human ERBB3/HER3 Antibody (SAA0123).
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