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| 카탈로그 번호 | HF753014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human ETHE1 Polyclonal Antibody (HF753014) is a rabbit polyclonal antibody detecting ETHE1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human ETHE1 (Ile23-Ala254). | ||||||||
| 타겟 | Persulfide dioxygenase ETHE1, mitochondrial, 1.13.11.18, Ethylmalonic encephalopathy protein 1, Hepatoma subtracted clone one protein, Sulfur dioxygenase ETHE1, ETHE1, HSCO | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O95571 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Persulfide dioxygenase ETHE1, mitochondrial is a ~27 kDa protein. Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus. 1. Higashitsuji, H. et al. (2002) Cancer cell 2, 335-46. PMID: 12398897 | ||||||||
| 참고사항 | For research use only. |
Western blot analysis was performed using anti-ETHE1 polyclonal antibody at ETHE1 on various samples.
Lane 1: Mouse kidney lysate
Lane 2: Mouse colon lysate
Lane 3: Rat liver lysate
Lane 4: Rat kidney lysate
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