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| 카탈로그 번호 | HC673013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||
| 응용 분야 | ELISA, IF, IP | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG | ||||
| 클론 ID | SAA0188 | ||||
| 타겟 | Fetal Alzheimer antigen, FALZ, Nucleosome-remodeling factor subunit BPTF, FAC1, BPTF, Fetal Alz-50 clone 1 protein, Bromodomain and PHD finger-containing transcription factor | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q12830 | ||||
| RRID | Anti-Human FALZ/BPTF IP Antibody (SAA0188) (abinScience Cat# HC673013, RRID:AB_3729722) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Nucleosome-remodeling factor subunit BPTF (FALZ) is a ~338 kDa protein. Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex. Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development. Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes. Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent. 1. Barak, O. et al. (2003) The EMBO journal 22, 6089-100. PMID: 14609955 2. Oppikofer, M. et al. (2017) EMBO reports 18, 1697-1706. PMID: 28801535 3. Wysocka, J. et al. (2006) Nature 442, 86-90. PMID: 16728976 4. Li, H. et al. (2006) Nature 442, 91-5. PMID: 16728978 5. Li, H. et al. (2007) Molecular cell 28, 677-91. PMID: 18042461 6. Jordan-Sciutto, KL. et al. (1999) The Journal of biological chemistry 274, 35262-8. PMID: 10575013 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human FALZ/BPTF IP Antibody (SAA0188)
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