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| 카탈로그 번호 | HP533014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human FBXO22 (Arg61-Lys403). | ||||||||
| 타겟 | FBX22, F-box protein FBX22p44, FBXO22, F-box only protein 22 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q8NEZ5 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | F-box only protein 22 (FBXO22) is a ~44 kDa protein. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that is implicated in the control of various cellular processes such as cell cycle control, transcriptional regulation, DNA damage repair, and apoptosis. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. Acts as a key regulator of histone methylation marks namely H3K9 and H3K36 methylation through the regulation of histone demethylase KDM4A protein levels. In complex with KDM4A, also regulates the abundance of TP53 by targeting methylated TP53 for degradation at the late senescent stage. Under oxidative stress, promotes the ubiquitination and degradation of BACH1. 1. Tan, MK. et al. (2011) Molecular and cellular biology 31, 3687-99. PMID: 21768309 2. Johmura, Y. et al. (2016) Nature communications 7, 10574. PMID: 26868148 3. Cao, S. et al. (2024) Cell 187, 7568-7584.e22. PMID: 39504958 4. Ge, MK. et al. (2023) Cell metabolism 35, 2216-2230.e8. PMID: 37979583 5. Zhou, Y. et al. (2024) Journal of medical virology 96, e29891. PMID: 39223933 | ||||||||
| 참고사항 | For research use only. |
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