中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HT233014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human FLIP/CFLAR (Asp31-Asn184). | ||||||||
| 타겟 | CLARP, Inhibitor of FLICE, Casper, CASP8 and FADD-like apoptosis regulator, Caspase homolog, I-FLICE, MRIT, CASP8AP1, CFLAR, Cellular FLICE-like inhibitory protein, Caspase-like apoptosis regulatory protein, c-FLIP, MACH-related inducer of toxicity, Usurpin, FADD-like antiapoptotic molecule 1, CASH, FLAME-1, Caspase-eight-related protein | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O15519 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | CASP8 and FADD-like apoptosis regulator (FLIP/CFLAR) is a ~55 kDa protein. Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. 1. An, W. et al. (2019) Journal of experimental & clinical cancer research : CR 38, 181. PMID: 31046799 | ||||||||
| 참고사항 | For research use only. |
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
