Anti-Human Frataxin Recombinant Nanobody (SAA2739) (HS777043)

Name: Anti-Human Frataxin Recombinant Nanobody (SAA2739)
Brand: abinScience
SKU: HS777043
Price: 191 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD):

사양:

50ug
100ug
1mg

수량:

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HS777043

설명

Anti-Human Frataxin Nanobody (SAA2739) [SAA2739] (HS777043) is a alpaca monoclonal antibody detecting Frataxin in ELISA. Suitable for Human.

종 반응성

Human

응용 분야

ELISA

숙주 종

Alpaca

클론성

Monoclonal

이소타입

VHH-His

클론 ID

SAA2739

타겟

EC:1.16.3.1, Extramitochondrial frataxin, FRDA, FXN, Frataxin intermediate form, Frataxin mature form, Frataxin(56-210), Frataxin(78-210), Frataxin(81-210), Frataxin, mitochondrial, Friedreich ataxia protein, Fxn, X25, d-FXN, i-FXN, m56-FXN, m78-FXN, m81-FXN

내독소 수준

Please contact with the lab for this information.

순도

>95% as determined by SDS-PAGE.

정제

Purified by Nickel column.

등록번호

Q16595

형태

Liquid

저장 완충액

0.01M PBS pH 7.4

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:2000-1:20000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Frataxin, mitochondrial is a ~23 kDa protein. Functions as an activator of persulfide transfer to the scaffoding protein ISCU as component of the core iron-sulfur cluster (ISC) assembly complex and participates to the [2Fe-2S] cluster assembly. Accelerates sulfur transfer from NFS1 persulfide intermediate to ISCU and to small thiols such as L-cysteine and glutathione leading to persulfuration of these thiols and ultimately sulfide release. Binds ferrous ion and is released from FXN upon the addition of both L-cysteine and reduced FDX2 during [2Fe-2S] cluster assembly. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner.

1. Yoon, T. et al. (2003) Journal of the American Chemical Society 125, 6078-84. PMID: 12785837

2. Bridwell-Rabb, J. et al. (2014) Biochemistry 53, 4904-13. PMID: 24971490

3. Cai, K. et al. (2018) Journal of inorganic biochemistry 183, 107-116. PMID: 29576242

4. O'Neill, HA. et al. (2005) Biochemistry 44, 537-45. PMID: 15641778

5. Cavadini, P. et al. (2002) Human molecular genetics 11, 217-27. PMID: 11823441

6. Nichol, H. et al. (2003) Biochemistry 42, 5971-6. PMID: 12755598

7. Bulteau, AL. et al. (2004) Science (New York, N.Y.) 305, 242-5. PMID: 15247478

8. Yoon, T. et al. (2004) The Journal of biological chemistry 279, 25943-6. PMID: 15123683

9. Schoenfeld, RA. et al. (2005) Human molecular genetics 14, 3787-99. PMID: 16239244

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human Frataxin Recombinant Nanobody (SAA2739).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human Frataxin Recombinant Nanobody (SAA2739) (HS777043)

개요

이미지

참고 문헌

데이터시트

SDS

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