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| 카탈로그 번호 | HC066023 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-Human FZD3/Frizzled-3 Nanobody (SAA2319) [SAA2319] (HC066023) is a human monoclonal antibody detecting Frizzled-3 in ELISA. Suitable for Human.
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| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Human | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | VHH-Fc | ||||
| 클론 ID | SAA2319 | ||||
| 타겟 | Frizzled-3, Fz-3, hFz3, FZD3 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q9NPG1 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Frizzled-3 (FZD3) is a ~76 kDa protein. Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. | ||||
| 참고사항 | For research use only |
SDS-PAGE for Anti-Human FZD3/Frizzled-3 Nanobody (SAA2319)
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중국 우한시 심둔사로 666번지 C동, 우한, 430206
