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| 카탈로그 번호 | HD415014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human GEMIN2 Polyclonal Antibody (HD415014) is a rabbit polyclonal antibody detecting GEMIN2. Suitable for Human, Mouse, and Rat.
Highlights
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| 종 반응성 | Human, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human GEMIN2 (Thr99-Ser280). | ||||||||
| 타겟 | Component of gems 2, GEMIN2, Gem-associated protein 2, Gemin-2, SIP1, SMN-interacting protein 1, Survival of motor neuron protein-interacting protein 1 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O14893 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | Gem-associated protein 2 (GEMIN2) is a ~31 kDa protein. The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. 1. Chari, A. et al. (2008) Cell 135, 497-509. PMID: 18984161 2. Liu, Q. et al. (1997) Cell 90, 1013-21. PMID: 9323129 3. Yi, H. et al. (2020) Nucleic acids research 48, 895-911. PMID: 31799625 4. Golembe, TJ. et al. (2005) Molecular and cellular biology 25, 10989-1004. PMID: 16314521 5. Zhang, R. et al. (2011) Cell 146, 384-95. PMID: 21816274 | ||||||||
| 참고사항 | For research use only |
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