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| 카탈로그 번호 | HW752014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human GNAQ Polyclonal Antibody (HW752014) is a rabbit polyclonal antibody detecting GNAQ in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human GNAQ (Met1-Val359). | ||||||||
| 타겟 | GNAQ, GAQ, Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein alpha-q | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P50148 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) is a ~42 kDa protein. Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. 1. Zhang, X. et al. (2021) Nature chemical biology 17, 1230-1237. PMID: 34556863 2. Ding, Y. et al. (2022) Cell discovery 8, 55. PMID: 35672283 3. Falzone, ME. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2315011120. PMID: 37991948 4. Alvarez-Curto, E. et al. (2016) The Journal of biological chemistry 291, 27147-27159. PMID: 27852822 | ||||||||
| 참고사항 | For research use only. |
Western blot analysis was performed using anti-GNAQ polyclonal antibody at 1μg/ml on various samples.
Lane 1: Jurkat cell lysate
Lane 2: Mouse brain lysate
Lane 3: Mouse cerebellum lysate
Lane 4: Mouse lung lysate
Lane 5: Rat brain lysate
Lane 6: Rat cerebellum lysate
Lane 7: Rat lung lysate
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