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| 카탈로그 번호 | HT096014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human GNB5 Polyclonal Antibody (HT096014) is a rabbit polyclonal antibody detecting GNB5 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human GNB5 (Met95-Ala395). | ||||||||
| 타겟 | Guanine nucleotide-binding protein subunit beta-5, GNB5, Gbeta5, Transducin beta chain 5 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O14775 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Guanine nucleotide-binding protein subunit beta-5 (GNB5) is a ~43 kDa protein. Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation. Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition. Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors. May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate. 1. Shamseldin, HE. et al. (2016) Genome biology 17, 195. PMID: 27677260 | ||||||||
| 참고사항 | For research use only. |
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