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| 카탈로그 번호 | HA179014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human GPBAR1 Polyclonal Antibody (HA179014) is a rabbit polyclonal antibody detecting GPBAR1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human GPBAR1. | ||||||||
| 타겟 | G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, hGPCR19, Membrane-type receptor for bile acids, M-BAR, hBG37, BG37, GPBAR1, TGR5 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q8TDU6 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | G-protein coupled bile acid receptor 1 (GPBAR1) is a ~35 kDa protein. G protein-coupled receptor for bile acid. Bile acid-binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. GPBAR1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Activated by bile acids, such as lithocholate, deoxycholate, chenodeoxycholate and cholate, in descending order. Apart from their role in lipid dietary absorption and cholesterol catabolism, bile acids act as an important signaling molecule, involved in processes, such as energy expenditure or tissue inflammation. 1. Maruyama, T. et al. (2002) Biochemical and biophysical research communications 298, 714-9. PMID: 12419312 2. Kawamata, Y. et al. (2003) The Journal of biological chemistry 278, 9435-40. PMID: 12524422 3. Yang, F. et al. (2020) Nature 587, 499-504. PMID: 32698187 4. Chen, G. et al. (2020) Signal transduction and targeted therapy 5, 142. PMID: 32747649 5. Ma, L. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2117054119. PMID: 35858343 | ||||||||
| 참고사항 | For research use only. |
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