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| 카탈로그 번호 | HC465014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human GRIN1/NMDAR1 (Asp23-His371). | ||||||||
| 타겟 | N-methyl-D-aspartate receptor subunit NR1, GluN1, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor ionotropic, NMDA 1, NMD-R1, GRIN1, NMDAR1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q05586 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Glutamate receptor ionotropic, NMDA 1 (GRIN1/NMDAR1) is a ~105 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. 1. Hamdan, FF. et al. (2011) American journal of human genetics 88, 306-16. PMID: 21376300 2. Hackos, DH. et al. (2016) Neuron 89, 983-99. PMID: 26875626 3. Volgraf, M. et al. (2016) Journal of medicinal chemistry 59, 2760-79. PMID: 26919761 4. Chen, W. et al. (2017) Molecular pharmacology 91, 317-330. PMID: 28126851 5. Chen, W. et al. (2017) Journal of human genetics 62, 589-597. PMID: 28228639 6. Zhang, J. et al. (2023) Nature structural & molecular biology 30, 629-639. PMID: 36959261 7. Karp, SJ. et al. (1993) The Journal of biological chemistry 268, 3728-33. PMID: 7679115 8. Younkin, DP. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 2174-8. PMID: 7681588 9. Planells-Cases, R. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 5057-61. PMID: 7685113 | ||||||||
| 참고사항 | For research use only. |
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