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| 카탈로그 번호 | HP555013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA, IF, IP | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG1 | ||||
| 클론 ID | SAA0202 | ||||
| 타겟 | HECT-type E3 ubiquitin transferase HACE1, HACE1, E3 ubiquitin-protein ligase HACE1, HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1, KIAA1320 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q8IYU2 | ||||
| RRID | Anti-Human HACE1 IP Antibody (SAA0202) (abinScience Cat# HP555013, RRID:AB_3729736) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | E3 ubiquitin-protein ligase HACE1 is a ~102 kDa protein. E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically binds GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. 1. Anglesio, MS. et al. (2004) Human molecular genetics 13, 2061-74. PMID: 15254018 2. Tang, D. et al. (2011) Nature communications 2, 501. PMID: 21988917 3. Torrino, S. et al. (2011) Developmental cell 21, 959-65. PMID: 22036506 4. Singh, S. et al. (2023) Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10, e2207672. PMID: 37537642 5. Düring, J. et al. (2024) Nature structural & molecular biology 31, 364-377. PMID: 38332367 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human HACE1 IP Antibody (SAA0202)
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