Anti-Human HLA-DQB1 Recombinant Antibody (LG11) (HM817023)

Anti-Human HLA-DQB1 Antibody (LG11) (abinScience Cat# HM817023, RRID:AB_3727817)
_x005F_x005F_x000D_ Copy Citation

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) is a ~29 kDa protein. Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components.