Anti-Human HLA-G Recombinant Antibody (15E7#) (HM815503)

Name: Anti-Human HLA-G Recombinant Antibody (15E7#)
Brand: abinScience
SKU: HM815503
Price: 126 USD
Availability: InStock

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사양:

20ug
50ug
100ug
1mg

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HM815503

종 반응성

Human

응용 분야

ELISA, FCM, SPR

숙주 종

Mouse

클론성

Monoclonal

이소타입

IgG2a, kappa

클론 ID

15E7#

타겟

HLA G antigen, HLA class I histocompatibility antigen, alpha chain G, HLA-6.0, HLA-G, HLAG, MHC class I antigen G, Soluble HLA class I histocompatibility antigen, alpha chain G, sHLA-G

내독소 수준

< 10 EU/mg

순도

>95% as determined by SDS-PAGE.

정제

Protein A/G purified from cell culture supernatant.

등록번호

P17693

형태

Liquid

저장 완충액

0.01M PBS pH 7.4.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:2000-1:20000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

HLA class I histocompatibility antigen, alpha chain G (HLA-G) is a ~38 kDa protein. Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface. In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins. Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance. Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy. Through interaction with KIR2DL4 receptor on decidual macrophages induces pro-inflammatory cytokine production mainly associated with tissue remodeling.

1. Li, C. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 5767-72. PMID: 19304799

2. Rajagopalan, S. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 20596-601. PMID: 23184984

3. Fu, B. et al. (2017) Immunity 47, 1100-1113.e6. PMID: 29262349

4. Lee, N. et al. (1995) Immunity 3, 591-600. PMID: 7584149

5. Diehl, M. et al. (1996) Current biology : CB 6, 305-14. PMID: 8805247

6. Rajagopalan, S. et al. (2006) PLoS biology 4, e9. PMID: 16366734

7. Gregori, S. et al. (2010) Blood 116, 935-44. PMID: 20448110

8. Köstlin, N. et al. (2017) European journal of immunology 47, 374-384. PMID: 27859042

9. Rajagopalan, S. et al. (1999) The Journal of experimental medicine 189, 1093-100. PMID: 10190900

참고사항

For research use only.

이미지

SDS-PAGE

SDS-PAGE for Anti-Human HLA-G Antibody (15E7#).

참고 문헌

데이터시트

Anti-Human HLA-G Recombinant Antibody (15E7#).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human HLA-G Recombinant Antibody (15E7#) (HM815503)

개요

이미지

참고 문헌

데이터시트

SDS

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