Anti-Human HNRNPL Polyclonal Antibody (HB914014)

Name: Anti-Human HNRNPL Polyclonal Antibody
Brand: abinScience
SKU: HB914014
Price: 96 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HB914014

설명

Anti-Human HNRNPL Polyclonal Antibody (HB914014) is a rabbit polyclonal antibody detecting HNRNPL in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human HNRNPL (Ser381-Ser589).

타겟

hnRNP L, HNRPL, Heterogeneous nuclear ribonucleoprotein L, HNRNPL

정제

Purified by antigen affinity column.

등록번호

P14866

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Heterogeneous nuclear ribonucleoprotein L (HNRNPL) is a ~64 kDa protein. Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation.

1. Kuninger, DT. et al. (2002) Nucleic acids research 30, 823-9. PMID: 11809897

2. Liu, G. et al. (2012) The Journal of biological chemistry 287, 22709-16. PMID: 22570490

3. Shankarling, G. et al. (2014) Molecular and cellular biology 34, 71-83. PMID: 24164894

4. Loh, TJ. et al. (2015) Biochimica et biophysica acta 1849, 743-50. PMID: 25623890

5. Blatter, M. et al. (2015) Journal of molecular biology 427, 3001-22. PMID: 26051023

6. Piñol-Roma, S. et al. (1989) The Journal of cell biology 109, 2575-87. PMID: 2687284

7. Hollensen, AK. et al. (2020) eLife 9. PMID: 33174841

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human HNRNPL Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human HNRNPL Polyclonal Antibody (HB914014)

개요

이미지

참고 문헌

데이터시트

SDS