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| 카탈로그 번호 | HP844014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human HORMAD1 Polyclonal Antibody (HP844014) is a rabbit polyclonal antibody detecting HORMAD1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human HORMAD1 (Ser21-Arg232). | ||||||||
| 타겟 | Cancer/testis antigen 46, CT46, HORMA domain-containing protein 1, NOHMA, Newborn ovary HORMA protein, HORMAD1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q86X24 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | HORMA domain-containing protein 1 (HORMAD1) is a ~45 kDa protein. Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. | ||||||||
| 참고사항 | For research use only. |
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