Anti-Human HTR6 Polyclonal Antibody (HA663014)

Name: Anti-Human HTR6 Polyclonal Antibody
Brand: abinScience
SKU: HA663014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HA663014

설명

Anti-Human HTR6 Polyclonal Antibody (HA663014) is a rabbit polyclonal antibody detecting 5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6; HTR6 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant human HTR6 (Pro321-Asn440).

타겟

5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6; HTR6

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P50406

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

5-hydroxytryptamine receptor 6 (HTR6) is a ~46 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Also has a high affinity for tricyclic psychotropic drugs. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity.

1. Huang, S. et al. (2022) Molecular cell 82, 2681-2695.e6. PMID: 35714614

2. He, L. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2209917120. PMID: 36989299

3. Pei, Y. et al. (2023) Biochemical and biophysical research communications 671, 327-334. PMID: 37327704

4. Kohen, R. et al. (1996) Journal of neurochemistry 66, 47-56. PMID: 8522988

5. Meffre, J. et al. (2012) EMBO molecular medicine 4, 1043-56. PMID: 23027611

참고사항

For research use only

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참고 문헌

데이터시트

Anti-Human HTR6 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human HTR6 Polyclonal Antibody (HA663014)

개요

이미지

참고 문헌

데이터시트

SDS