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| 카탈로그 번호 | HX050014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human IFI35 Polyclonal Antibody (HX050014) is a rabbit polyclonal antibody detecting IFI35 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human IFI35 (Ser2-Gly286). | ||||||||
| 타겟 | IFI35, IFP 35, Ifi-35, Interferon-induced 35 kDa protein, IFP35 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P80217 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Interferon-induced 35 kDa protein (IFI35) is a ~31 kDa protein. Acts as a signaling pathway regulator involved in innate immune system response. In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation. In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production. In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries. Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion. 1. Das, A. et al. (2015) Virology 485, 383-92. PMID: 26342464 2. Xiahou, Z. et al. (2017) Nature communications 8, 950. PMID: 29038465 3. Jian, D. et al. (2018) Acta physiologica (Oxford, England) 223, e13037. PMID: 29350881 4. Zhou, X. et al. (2000) The Journal of biological chemistry 275, 21364-71. PMID: 10779520 5. Chen, J. et al. (2000) The Journal of biological chemistry 275, 36278-84. PMID: 10950963 | ||||||||
| 참고사항 | For research use only. |
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