Anti-Human IFIT1 Polyclonal Antibody (HY426014)

Name: Anti-Human IFIT1 Polyclonal Antibody
Brand: abinScience
SKU: HY426014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HY426014

설명

Anti-Human IFIT1 Polyclonal Antibody (HY426014) is a rabbit polyclonal antibody detecting IFIT1 in ELISA, IHC, WB. Suitable for Human and Macaca fascicularis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human IFIT1 (Met1-Pro478).

타겟

IFI-56K, G10P1, Interferon-induced protein with tetratricopeptide repeats 1, IFIT-1, IFNAI1, IFIT1, ISG56, IFI56, Interferon-induced 56 kDa protein, P56

정제

Purified by antigen affinity column.

등록번호

P09914

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Antiviral innate immune response effector IFIT1 is a ~55 kDa protein. Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E. Could also prevent viral replication through its interaction with DNA replication origin-binding protein E1 of several viruses. Causes the translocation of E1 from the nucleus to the cytoplasm and can also inhibit its helicase activity in vitro. Exhibits antiviral activity against many viruses from the Flaviviridae (West Nile virus, Dengue virus, hepatitis C virus), Coronaviridae (human 229E coronavirus, SARS-CoV-2 and SARS-CoV), Poxviridae (vaccinia virus) and Togaviridae (Sindbis virus) families.

1. Pichlmair, A. et al. (2011) Nature immunology 12, 624-30. PMID: 21642987

2. Daugherty, MD. et al. (2016) eLife 5. PMID: 27240734

3. Geng, J. et al. (2024) RNA (New York, N.Y.) 30, 1292-1305. PMID: 39009378

4. Abbas, YM. et al. (2013) Nature 494, 60-4. PMID: 23334420

5. Abbas, YM. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2106-E2115. PMID: 28251928

6. Russ, A. et al. (2022) EMBO reports 23, e55648. PMID: 36285486

7. Terenzi, F. et al. (2008) The EMBO journal 27, 3311-21. PMID: 19008854

8. Raychoudhuri, A. et al. (2011) Journal of virology 85, 12881-9. PMID: 21976647

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human IFIT1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human IFIT1 Polyclonal Antibody (HY426014)

개요

이미지

참고 문헌

데이터시트

SDS