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| 카탈로그 번호 | HB936107 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | ELISA, FCM |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG2a, kappa |
| 클론 ID | SAA0380 |
| 타겟 | IL-12A, NK cell stimulatory factor chain 1, IL12A, CLMF p35, Interleukin-12 subunit alpha, IL-12 subunit p35, NKSF1, Cytotoxic lymphocyte maturation factor 35 kDa subunit |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P29459 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.09% Sodium azide. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | Interleukin-12 subunit alpha (IL12A/IL-12 p35) is a ~24 kDa protein. Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. 1. Heufler, C. et al. (1996) European journal of immunology 26, 659-68. PMID: 8605935 2. Presky, DH. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 14002-7. PMID: 8943050 3. Wolf, SF. et al. (1991) Journal of immunology (Baltimore, Md. : 1950) 146, 3074-81. PMID: 1673147 4. Gubler, U. et al. (1991) Proceedings of the National Academy of Sciences of the United States of America 88, 4143-7. PMID: 1674604 5. Bacon, CM. et al. (1995) The Journal of experimental medicine 181, 399-404. PMID: 7528775 6. Bacon, CM. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 7307-11. PMID: 7638186 7. Collison, LW. et al. (2012) Nature immunology 13, 290-9. PMID: 22306691 |
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human IL12A/IL-12 p35/NKSF1 Antibody (SAA0380)
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