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| 카탈로그 번호 | HB936147 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | ELISA, FCM |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG2a, kappa |
| 클론 ID | SAA0380 |
| 접합 | PerCP |
| 타겟 | IL-12A, NK cell stimulatory factor chain 1, IL12A, CLMF p35, Interleukin-12 subunit alpha, IL-12 subunit p35, NKSF1, Cytotoxic lymphocyte maturation factor 35 kDa subunit |
| 내독소 수준 | Please contact with the lab for this information. |
| 관련 제품 | Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), PerCP |
| 등록번호 | P29459 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 배경 | Interleukin-12 subunit alpha (IL12A/IL-12 p35) is a ~24 kDa protein. Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. 1. Heufler, C. et al. (1996) European journal of immunology 26, 659-68. PMID: 8605935 2. Presky, DH. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 14002-7. PMID: 8943050 3. Wolf, SF. et al. (1991) Journal of immunology (Baltimore, Md. : 1950) 146, 3074-81. PMID: 1673147 4. Gubler, U. et al. (1991) Proceedings of the National Academy of Sciences of the United States of America 88, 4143-7. PMID: 1674604 5. Bacon, CM. et al. (1995) The Journal of experimental medicine 181, 399-404. PMID: 7528775 6. Bacon, CM. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 7307-11. PMID: 7638186 7. Collison, LW. et al. (2012) Nature immunology 13, 290-9. PMID: 22306691 |
| 참고사항 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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